Child Turcotte Pugh (CTP) and Model for End-stage Liver Disease (MELD) scores are commonly used to assess the prognosis of liver disease but major disadvantage of static liver function tests is their inability to identify the functional reserve of the liver. Liver function tests can be broadly divided into static tests and dynamic tests i.e. The sensitivity and specificity of MELD score was 60% and 80% respectively while that of ICGR15 was 85% and 90% respectively.Ĭonclusion: ICGR15 has a higher sensitivity and specificity than MELD score in assessing the prognosis of patients with cirrhosis of liver. 0.88 for ICGR15 in assessing prognosis of patients with cirrhosis. On ROC curve analysis, AUC for MELD was 0.805 vs. MELD score had a strong positive correlation with ICGR15 but a negative correlation with ICG clearance rate. ICG clearance rates were 4.3% + 2.8% and 3.5% + 3.8% per minute in group A and B respectively. After ICG injection, ICG retention at 15 minutes (ICGR15) and ICG clearance rate were calculated. Group A had 20 patients with CTP class A and group B had 20 patients with CTP class B. Methods: Forty patients with cirrhosis of liver were included and divided into two groups according to their CTP scores. Among all quantitative liver function tests indocyanine green (ICG) clearance test is most widely used and has been used to determine operative risk before hepatectomy and to assess prognosis of patients with cirrhosis.Īim: To correlate indocyanine green (ICG) clearance test with MELD score in patients with cirrhosis of liver.
Post Graduate Institute of Medical Education and Research,Įmail: Child Turcotte Pugh (CTP) score and Model for End Stage Liver Disease (MELD) are used commonly to assess the prognosis of liver disease but the disadvantage of these static tests is their inability to identify the functional reserve of the liver. Sachin Gupta, 1 Yogesh Chawla, 1 Jyotdeep Kaur, 2 Roli Saxena, 2 Ajay Duseja, 1 RK Dhiman, 1 Narendra S Choudhary 1 Keywords : Cirrhosis of liver, Child Turcott Pugh score, Model for End Stage Liver Disease, indocyanine green clearance test. Indocyanine green clearance test (using spectrophotometry) and its correlation with Model for End Stage Liver Disease (MELD) score in Indian patients with cirrhosis of liver